Primary breast angiosarcoma: a case report
DOI:
https://doi.org/10.20453/rmh.v35i3.5345Keywords:
Hemangiosarcoma, breast neoplasms, primary sarcomaAbstract
We report the case of a 46-year-old woman with no previous history who was attended for screening. Mammography revealed an ovoidal nodule of mixed density with well-defined borders in the right breast that had positive flow at the Doppler examination, highly suspicious of malignancy. An ultrasound-guided biopsy was performed, revealing neoplastic vascular proliferation compatible with low-grade angiosarcoma. A total right mastectomy was performed, and the patient is under follow-up evaluation with no evidence of recurrence. This report highlights the clinical presentation of an infrequent malignant breast neoplastic condition where the combination of images makes the diagnosis.
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Abdou Y, Elkhanany A, Attwood K, Ji W, Takabe K, Opyrchal M. Primary and secondary breast angiosarcoma: Single center report and a meta-analysis. Breast Cancer Res Treat. 2019;178(3):523–33. Doi: 10.1007/s10549-019-05432-4.
Karlsson F, Granath F, Smedby KE, Zedenius J, Bränström R, Nilsson I-L. Sarcoma of the breast: breast cancer history as etiologic and prognostic factor—A population-based case–control study. Breast Cancer Res Treat. 2020 10;183(3):669-675. Doi: 10.1007/s10549-020-05802-3.
Yin M, Wang W, Drabick JJ, Harold HA. Prognosis and treatment of non-metastatic primary and Secondary Breast Angiosarcoma: A comparative study. BMC Cancer. 2017; 17(1):8. Doi:10.1186/s12885-017-3292-7.
Lim SZ, Ong KW, Tan BK, Selvarajan S, Tan PH. Sarcoma of the breast: An update on a rare entity. J Clin Pathol. 2016; 69(5):373–81. Doi: 10.1136/jclinpath-2015-203545.
Enzinger FM, Weiss SW. Soft Tissue Tumors. 2a ed. Londres, Inglaterra: Mosby; 1988.
Masai K, Kinoshita T, Jimbo K, Asaga S, Hojo T. Clinicopathological features of breast angiosarcoma. Breast Cancer. 2015;23(5):718–23. Doi: 10.1007/s12282-015-0630-y.
Varghese B, Deshpande P, Dixit S, Koppiker C, Jalnapurkar N. Primary angiosarcoma of the breast: A case report. J Radiol Case Rep. 2019; 13(2):15-25. Doi: 10.3941/jrcr.v13i2.3449.
Darre T, Djiwa T, N'Timon B, Simgban P, Tchaou M, Napo-Koura G. Breast Primary Angiosarcoma: A Clinicopathologic and Imaging Study of a Series Cases. Breast Cancer (Auckl). 2022 Mar 29; 16:117822342210867. Doi: 10.1177/11782234221086726.
Glazebrook KN, Magut MJ, Reynolds C. Angiosarcoma of the breast. Am J Roentgenol. 2008 Feb;190(2):533-8. Doi: 10.2214/AJR.07.2909
Zahir ST, Sharahjin NS, Rahmani K. Primary Breast Angiosarcoma: Pathological and Radiological Diagnosis. Malays J Med Sci. 2014 Sep;21(5):66-70.
WHO Classification of Tumours Editorial Board. Breast Tumours. WHO Classification of Tumors, 5th Edition, Volume 2. Lyon: International Agency For Research On Cancer; 2019.
Donnell RM, Rosen PP, Lieberman PH, Kaufman RJ, Kay S, Braun DW, et al. Angiosarcoma and other vascular tumors of the breast. Am J Surg Pathol. 1981 Oct;5(7):629–42. Doi: 10.1097/00000478-198110000-00005.
Bland KI, Copeland EM, Copeland EM III. The breast: A comprehensive management of benign and malignant diseases. 2a ed. Londres, Inglaterra: W B Saunders; 1998.
Nascimento AF, Raut CP, Fletcher CDM. Primary Angiosarcoma of the Breast: Clinicopathologic Analysis of 49 Cases, Suggesting That Grade is not Prognostic. Am J Surg Pathol. 2008 Dec 1;32(12):1896–904. Doi: 10.1097/PAS.0b013e318176dbc7.
Toesca A, Spitaleri G, De Pas T, Botteri E, Gentilini O, Bottiglieri L, et al. Sarcoma of the breast: Outcome and reconstructive options. Clin Breast Cancer. 2012;12(6):438–44. Doi: 10.1016/j.clbc.2012.09.008.
Hodgson NC, Bowen-Wells C, Moffat F, Franceschi D, Avisar E. Angiosarcomas of the breast: A review of 70 cases. Am J Clin Oncol. 2007;30(6):570–3. Doi: 10.1097/COC.0b013e3181131d62.
Kim Y-J, Ryu J-M, Lee S-K, Chae B-J, Kim S-W, Nam S-J, et al. Primary angiosarcoma of the breast: A single-center retrospective study in Korea. Curr Oncol. 2022;29(5):3272–81. Doi: 10.3390/curroncol29050267.
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Copyright (c) 2024 Giuliana del Carmen Aliaga Pérez, Mercedes del Pilar Montenegro-Rojas, Richard Dyer-Velarde-Álvarez, Franco Doimi-García
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