Comparative study of oral squamous cell carcinoma over three decades at a teaching dental center in Lima, Peru

Authors

DOI:

https://doi.org/10.20453/reh.v35i4.5598

Keywords:

squamous cell carcinoma, oral cancer, mouth neoplasms

Abstract

Objective: To compare the frequency of oral squamous cell carcinoma in an oral and maxillofacial pathology laboratory at a teaching dental center of a Peruvian university across three decades (1991 -2020). Materials and methods: A cross-sectional, observational, descriptive, retrospective study was conducted. Age group, sex, clinical manifestations, anatomical location, and decade were analyzed. Collected data were coded to preserve patient anonymity and recorded on standardized data collection form. Statistical analysis was performed using STATA 16.0 software, applying the chi-square test and Fisher's exact test, with a 95% confidence level and p < 0.05. Results: A total of 735 records were included, the mean age was 53 years. The age group with the highest frequency was 70-79 years (n = 177). The main clinical manifestations were tumors (50.75 %) and ulcers (31.68 %). The most frequent anatomical sites were the upper and lower alveolar ridge/gingiva (35.80%) and the lateral border of the tongue (23.58%). Conclusions: An increase in oral squamous cell carcinoma was observed in the most recent decade (2011-2020), with a higher prevalence in females. The most frequent anatomical sites were the upper and lower alveolar ridge/gingiva and the lateral border of the tongue. The most common clinical manifestations were tumor, ulcer, and white plaque, in that order.

Downloads

Download data is not yet available.

Author Biographies

Gianella Dayana Garay Orihuela, Universidad Peruana Cayetano Heredia. Lima, Perú.

    

Karina Julia Morón Ayala, autor

Podría ser Cirujana Dentista, Predocente de DACE, con diplomado en IMPLANTOLOGIA

Sonia Julia Sacsaquispe Contreras, Universidad Peruana Cayetano Heredia. Lima, Perú.

Docente en la UPCH.

References

World Health Organization. Oral health [Internet]. WHO; 2022, 17 de marzo. Disponible en: https://www.who.int/news-room/fact-sheets/detail/oral-health

Montalban Y, Vázquez E, Meriño YP, Lotti R. Caracterización clínica y epidemiológica del carcinoma epidermoide de lengua. Rev Cubana Otorrinolaringol Cir Cabeza Cuello [Internet]. 2022; 6(3): e363. Disponible en: http://revotorrino.sld.cu/index.php/otl/article/view/363

Santelices MJ, Cárcamo M, Brenner C, Montes R. Cáncer oral en Chile: revisión de la literatura. Rev Méd Chile [Internet]. 2016; 144(6): 766-770. Disponible en: http://doi.org/10.4067/S0034-98872016000600011

Tarle M, Lukšić I. Pathogenesis and therapy of oral carcinogenesis. Int J Mol Sci [Internet]. 2024; 25(12): 6343. Disponible en: https://doi.org/10.3390/ijms25126343

Li Y, Hecht SS. Carcinogenic components of tobacco and tobacco smoke: a 2022 update. Food Chem Toxicol [Internet]. 2022; 165: 113179. Disponible en: https://doi.org/10.1016/j.fct.2022.113179

Torres Y, Rodríguez O, Herrera R, Burgos GJ, Mesa R. Factores pronósticos del cáncer bucal: revisión bibliográfica. Mediciego [Internet]. 2016; 22(3): 67-77. Disponible en: https://revmediciego.sld.cu/index.php/mediciego/article/view/419

Álvarez D, Munyo A, Borche G, D’Albora R, Rodríguez V, Cuello M. Cáncer de cabeza y cuello en Uruguay: análisis de sobrevida en dos centros de referencia. Rev Méd Urug [Internet]. 2018; 34(1): 21-28. Disponible en: https://revista.rmu.org.uy/index.php/rmu/article/view/38

Delesma AF. Prevalencia del carcinoma epidermoide en el Servicio de Cirugía Cabeza y Cuello del Hospital Nacional Dos de Mayo durante el periodo 2005-2016. Rev Odontol Sanmarquina [Internet]. 2018; 21(2): 113-118. Disponible en: http://doi.org/10.15381/os.v21i2.14776

World Health Organization. Tobacco [Internet]. WHO; 2025, 25 de junio. Disponible en: https://www.who.int/news-room/fact-sheets/detail/tobacco

González-Moles MÁ, Aguilar-Ruiz M, Ramos-García P. Challenges in the early diagnosis of oral cancer, evidence gaps and strategies for improvement: a scoping review of systematic reviews. Cancers [Internet]. 2022; 14(19): 4967. Disponible en: https://doi.org/10.3390/cancers14194967

Organización Panamericana de la Salud. La carga de cánceres malignos [Internet]. OPS; 2021. Disponible en: https://www.paho.org/es/enlace/carga-canceres-malignos

Instituto Nacional de Enfermedades Neoplásicas (PE). [Casos nuevos de cáncer registrados en el INEN, según el sexo, 2000-2019] [Internet]. Lima: INEN; 2022. Disponible en: https://portal.inen.sld.pe/wp-content/uploads/2022/08/Casos-nuevos-registrados-en-el-INEN-2000-2019.pdf

Gilligan G, Panico R, Lazos J, Morelatto R, Belardinelli P, Criscuolo MI, et al. Oral squamous cell carcinomas and oral potentially malignant disorders: a Latin American study. Oral Diseases [Internet]. 2024; 30(5): 2965-2984. Disponible en: https://doi.org/10.1111/odi.14778

Torres-Morales Y, Rodríguez-Martín O, Rodríguez-Rodríguez N, Viera-Morales KB, Díaz-Hernández MJ, Marichal-Martínez YA. Factores pronósticos del carcinoma epidermoide bucal. Mediciego [Internet]. 2020; 26(2): e1273. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=98851

García C, Salas M, Gil JM. Algunas consideraciones sobre etiología y fisiopatogenia del carcinoma epidermoide bucal. Medisur [Internet]. 2018; 16(1): 63-75. Disponible en: https://pesquisa.bvsalud.org/portal/resource/pt/biblio-894806

Rodríguez BV, Agustin P, Pérez-de-Oliveira ME, Ajudarte M, Kowalski LP, Curado MP. Epidemiology and survival outcomes of lip, oral cavity, and oropharyngeal squamous cell carcinoma in a southeast Brazilian population. Med Oral Patol Oral Cir Bucal [Internet]. 2022; 27(3): e274-e284. Disponible en: https://doi.org/10.4317/medoral.25147

Banco Mundial. Población, total - Perú [base de datos en Internet]. Washington (DC): Banco Mundial; 2022. Disponible en: https://datos.bancomundial.org/indicador/SP.POP.TOTL?locations=PE

De la Fuente M, Díaz M, Martínez B. Carcinoma espinocelular de lengua: estudio de sobrevida de 5 años. Rev Clín Periodoncia Implantol Rehabil Oral [Internet]. 2016; 9(1): 74-78. Disponible en: http://doi.org/10.1016/j.piro.2016.01.001

Acero J, Pastor Á, Haddad A, Baranda E, Bueno Á, Picón M, et al. Carcinoma epidermoide de cavidad oral en edad pediátrica. A propósito de un caso. Revisión de la literatura. Lat Am J Oral Maxillofac Surg [Internet]. 2022; 2(1): 6-11. Disponible en: https://doi.org/10.35366/103403

Barros AT, Silva CC, Dos Santos VC, Panjwani CM, Barbosa KG, Ferreira SM. Knowledge of oral and oropharyngeal cancer by dental surgeons: an integrative review. Rev Bras Enferm [Internet]. 2021; 74(1): e20200080. Disponible en: https://doi.org/10.1590/0034-7167-2020-0080

Published

2025-12-30

How to Cite

1.
Garay Orihuela GD, Morón Ayala KJ, Sacsaquispe Contreras SJ. Comparative study of oral squamous cell carcinoma over three decades at a teaching dental center in Lima, Peru. Rev Estomatol Herediana [Internet]. 2025 Dec. 30 [cited 2025 Dec. 31];35(4):297-303. Available from: http://44.198.254.164/index.php/REH/article/view/5598

Issue

Section

ORIGINAL ARTICLES

Most read articles by the same author(s)