Candidemia and antifungal susceptibility in Peruvian hospitals

Autores

  • Romina Rios-Blanco Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0003-2149-4540
  • Marcello Olsen-Verme Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-0007-2050
  • Fiorella Palomino Escalante Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru
  • Michelle Regal Ludowieg Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-0751-5328
  • Jan Jacobs Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium / Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium https://orcid.org/0000-0002-8657-6777
  • Fiorella Krapp Lopez Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-8404-2827
  • Beatriz Bustamante Rufino Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-6826-5211
  • Coralith García Apac Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru https://orcid.org/0000-0002-7933-1843

DOI:

https://doi.org/10.20453/rmh.v36i2.6233

Palavras-chave:

Antifungal agents, Candida, Candidemia, Antifungal Drug Resistance

Resumo

Worldwide, Candida bloodstream infections have presented an increase in non-albicans Candida species and resistance to antifungal agents. Objective: To describe the microbiological characteristics of consecutive Candida blood culture isolates. Methods: This study analyzed 73 consecutive Candida blood isolates recovered between July 2017 and July 2019 from routine patient care at 15 Peruvian hospitals, assessing susceptibility to four antifungal agents. Results: The species most frequently detected were Candida parapsilosis 39 (53.4%), Candida albicans 23 (31.5%), and Candida tropicalis 5 (6.8%). Conclusions: All isolates were susceptible to amphotericin B, fluconazole, voriconazole, and anidulafungin. There is a predominance of non-albicans Candida cases in Peru and a high susceptibility to current antifungal drugs.

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Biografia do Autor

Romina Rios-Blanco, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

Romina Rios is a medical doctor from Peru and a master's student in Global Health at ISGlobal, Universitat de Barcelona. Her research interests include infectious diseases, public health, and clinical guideline development. She has experience in clinical and public health research in Latin America and is currently involved in studies on candidemia in Peru and other global health challenges.

Marcello Olsen-Verme, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru

Marcello Olsen Verme graduated from the Universidad Peruana Cayetano Heredia Facultad de Medicina Alberto Hurtado. He currently works in Bronx, NY, specializing in Internal Medicine, with a strong interest in clinical research and infectious diseases.

Fiorella Palomino Escalante, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru

Fiorella Palomino is a Peruvian physician graduated from the Universidad Peruana Cayetano Heredia. She has a strong interest in research and public health.

Michelle Regal Ludowieg, Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru

Dr. Michelle Regal Ludowieg is a physician based in Washington, DC, specializing in Obstetrics & Gynecology. She is dedicated to providing comprehensive care in women's health, with a focus on both preventative and clinical aspects of obstetrics and gynecology.

Jan Jacobs, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium / Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

Dr. Jan Jacobs is a medical professional affiliated with the Department of Clinical Sciences at the Institute of Tropical Medicine in Antwerp, Belgium, and the Department of Microbiology, Immunology, and Transplantation at KU Leuven, Leuven, Belgium. His work focuses on tropical medicine, microbiology, and immunology, with a particular interest in infectious diseases and global health.

Fiorella Krapp Lopez, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

Dr. Fiorella Krapp is a Medical Doctor from the Universidad Peruana Cayetano Heredia (UPCH), specializing in Internal Medicine from Washington University in St. Louis and Infectious Diseases from Northwestern University. She holds a Master's in Clinical Research and a Ph.D. in Biomedical Sciences, Microbiology, and Immunology from the Catholic University of Leuven (KU Leuven, Belgium). She is currently a faculty member at the Faculty of Medicine and an Associate Researcher at the Alexander von Humboldt Institute of Tropical Medicine at UPCH. Her research focuses on antimicrobial resistance, with multiple projects on its impact, resistance mechanisms, and virulence in Peru, particularly in Gram-negative bacteria.

Beatriz Bustamante Rufino, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

Dr. Beatriz Bustamante is the Head of the Clinical Mycology Unit at the Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia in Lima, Peru. She specializes in clinical mycology, focusing on fungal infections and their treatment. Her work contributes to advancing the understanding and management of mycological diseases in Peru.

Coralith García Apac, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

Dr. Coralith García is a physician and specialist in Infectious and Tropical Diseases, graduated from the Universidad Peruana Cayetano Heredia, where she is currently an associate professor. She works as an assistant physician at the Hospital Nacional Cayetano Heredia and is a full member of the Alexander von Humboldt Institute of Tropical Medicine. Her research focuses on antimicrobial resistance, healthcare-associated infections, and antibiotic use.

Referências

Soriano A, Honore PM, Puerta-Alcalde P, et al. Invasive candidiasis: current clinical challenges and unmet needs in adult populations. J Antimicrob Chemother. 2023;78(7):1569–1585. doi:10.1093/jac/dkad139.

Chow JK, Golan Y, Ruthazer R, et al. Factors associated with candidemia caused by non‐albicans Candida species versus Candida albicans in the intensive care unit. Clin Infect Dis. 2008;46(8):1206-1213. doi:10.1086/529435.

da Matta D. Revisiting species distribution and antifungal susceptibility of Candida bloodstream isolates from Latin American medical centers. J Fungi. 2017;3(2):24. doi:10.3390/jof3020024.

Huang YT, Liu CY, Liao CH, Chung KP, Sheng WH, Hsueh PR. Antifungal susceptibilities of Candida isolates causing bloodstream infections at a medical center in Taiwan, 2009-2010. Antimicrob Agents Chemother. 2014;58(7):3814-3819. doi:10.1128/aac.01035-13.

Bustamante B, Martins MA, Bonfietti LX, et al. Species distribution and antifungal susceptibility profile of Candida isolates from bloodstream infections in Lima, Peru. J Med Microbiol. 2014;63(6):855-860. doi:10.1099/jmm.0.071167-0

Rodriguez L, Bustamante B, Huaroto L et al. A multi-centric Study of Candida bloodstream infection in Lima-Callao, Peru: species distribution, antifungal resistance and clinical outcomes. PLOS ONE. 2017;12(4):e0175172. doi:10.1371/journal.pone.0175172

F Krapp F, García C, Hinostroza N et al. Prevalence of antimicrobial resistance in gram-negative bacteria bloodstream infections in Peru and associated outcomes: VIRAPERU study. Am J Trop Med Hyg. 2023;109(5):1095-1106. doi:10.4269/ajtmh.22-0556.

CLSI. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard: M27, 4th ed. Clinical and Laboratory Standards Institute; 2017.

CLSI. Epidemiological Cutoff Values for Antifungal Susceptibility Testing: Supplement M59, 3rd ed. CLSI. Clinical and Laboratory Standard Institute; 2020.

Luo G, Mitchell TG. Rapid identification of pathogenic fungi directly from cultures by using multiplex PCR. J Clin Microbiol. 2002;40(8):2860-2865. doi:10.1128/jcm.40.8.2860-2865.2002.

CLSI. Performance Standards for Antifungal Susceptibility Testing of Yeasts: Supplement M60, 2nd ed. Clinical and Laboratory Standards Institute; 2020.

Doi AM, Pignatari AC, Edmond MB, et al. Epidemiology and microbiologic characterization of nosocomial candidemia from a Brazilian national surveillance program. PLOS ONE. 2016;11(1):e0146909. doi:10.1371/journal.pone.0146909.

Montagna MT, Caggiano G, Lovero G, et al. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project). Infection. 2013;41(3):645-653. doi:10.1007/s15010-013-0432-0.

Ma CF, Li FQ, Shi LN, et al. Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China. BMC Infect Dis. 2013;13(1):337. doi:10.1186/1471-2334-13-337.

Cortés JA, Reyes P, Gómez CH, et al. Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia. Braz J Infect Dis. 2014;18(6):631-637. doi:10.1016/j.bjid.2014.06.009.

Tan TY, Hsu LY, Alejandria MM et al. Antifungal susceptibility of invasive Candida bloodstream isolates from the Asia-Pacific region. Med Mycol. 2016;54(5):471-477. doi:10.1093/mmy/myv114.

Garzillo C, Bagattini M, Bogdanović L et al. Risk factors for Candida parapsilosis bloodstream infection in a neonatal intensive care unit: a case-control study. Ital J Pediatr. 2017;43(1):10. doi:10.1186/s13052-017-0332-5.

Dannaoui E, Espinel-Ingroff A. Antifungal Susceptibility Testing by Concentration Gradient Strip Etest Method for Fungal Isolates: A Review. J Fungi. 2019;5(4):108. doi:10.3390/jof5040108.

Jamiu AT, Albertyn J, Sebolai OM, Pohl CH. Update on Candida krusei, a potential multidrug-resistant pathogen. Med Mycol. 2020;59(1):14-30. doi:10.1093/mmy/myaa031.

Nucci M, Queiroz-Telles F, Alvarado-Matute T et al. Epidemiology of candidemia in Latin America: a laboratory-based survey. PLOS ONE. 2013;8(3):e59373. doi:10.1371/journal.pone.0059373.

Krapp F, Rondon C, Amaro C, et al. Underutilization and quality gaps in blood culture processing in public hospitals of Peru. Am J Trop Med Hyg. 2022;106(2):432-440. doi:10.4269/ajtmh.21-0770.

Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2016;62(4):e1-50. doi:10.1093/cid/civ933.

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Publicado

2025-06-30

Como Citar

1.
Rios-Blanco R, Olsen-Verme M, Palomino Escalante F, Regal Ludowieg M, Jacobs J, Krapp Lopez F, et al. Candidemia and antifungal susceptibility in Peruvian hospitals. Rev Méd Hered [Internet]. 30º de junho de 2025 [citado 17º de julho de 2025];36(2):130-5. Disponível em: http://44.198.254.164/index.php/RMH/article/view/6233

Edição

v. 36 n. 2 (2025): Abril-junio

Seção

COMUNICACION CORTA

Licença

Copyright (c) 2025 Romina Rios Blanco, Marcello Olsen Verme, Fiorella Palomino Escalante, Michelle Regal Ludowieg, Jan Jacobs, Fiorella Krapp Lopez, Beatriz Bustamante Rufino, Coralith García Apac

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

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