von Willebrand disease: practical considerations for the dentist. Literature review.

Authors

  • María del Carmen Navas-Aparicio University of Costa Rica, San Jose, Costa Rica
  • Alejandro Acuña-Navas Independient researcher

DOI:

https://doi.org/10.20453/reh.v32i2.4214

Keywords:

von Willebrand factor, von Willebrand disease, hemorrhagic disorders, blood coagulation disorders, hemorrhage, blood coagulation

Abstract

von Willebrand disease is the most common inherited bleeding disorder, caused by von Willebrand factor deficiency, which causes defective platelet adhesion and aggregation. It is characterized by a prolonged bleeding time and partial thromboplastin time, with low levels of factor VIII, and increased capillary fragility, but with a normal platelet count. Dental treatment in a patient with von Willebrand disease must be individualized according to the severity of the patient’s condition, as well as coordinated with the hematologist, who must determine the type of disease and the need for factor replacement therapy, prior to the patient management. Through this bibliographic review, it wants to reinforce the dentist’s knowledge of this bleeding disorder, since this can prevent or minimize possible bleeding complications during dental treatment.

Downloads

Download data is not yet available.

References

Jover-Cerveró A, Poveda-Roda R, Bagán JV, Jiménez-Soriano Y. Dental treatment of patients with coagulation factor alteration: an update. Med Oral Patol Oral Cir Bucal. 2007; 12(5): E380-7.

Israels S, Schwetz N, Boyar R, McNicol A. Bleeding disorders: Characterization, dental considerations and management. J Can Dent Assoc. 2006; 72(9): 827.

Bernardoni C, Benito M, Pereira S, Bracho M. Manejo odontológico del paciente con trastornos hemorrágicos. Una revisión. Ciencia Odontológica. 2004; 1(1): 60-70.

Woods AI, Blanco AN, Kempfer AC, Paiva J, Bermejo EI, Sánchez A. Lazzari MA. Factor von Willebrand y Enfermedad de von Willebrand: nuevos enfoques diagnósticos. Acta Bioquím Clín Latinoam. 2016; 50 (2): 273-89. http://www.redalyc.org/articulo.oa?id=53549261012

Leebeek FWG, Atiq F. How I manage severe von Willebrand disease. Br J Haematol. 2019; 187(4): 418–30. DOI: 10.1111/bjh.16186

Cano-Franco MA, Ortiz-Orrego GE, González-Ariza SE. Cuidado odontológico de pacientes con trastornos hereditarios de la coagulación. Rev CES Odont. 2017; 30(1): 30-40. DOI: 10.21615/cesodon.30.1.3

Martínez-Murillo C. Enfermedad de von Willebrand. El reto en el diagnóstico y el tratamiento. Rev Hematol Mex. 2018; 19(2): 61-72.

van Galen KPM, Engelen ET, Mauser-Bunschoten EP, van Es RJJ, Schutgens REG. Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions (Review). Cochrane Database of Systematic Review. 2019; (4). DOI: 10.1002/14651858.CD011385.pub3

Castaman G, Linari S. Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A. Ther Clin Risk Manag. 2016:12: 1029-37. DOI: 10.2147/tcrm.s87543

Rivera S, González P. Manejo clínico de los pacientes portadores de coagulopatías congénitas. Revista Dental de Chile. 2001; 92(2): 29-33.

Peyvandi F, Jayandharan G, Chandy M, Srivastava A, Nakaya SM, Johnson MJ, et al. Genetic Diagnosis of haemophilia and other inherited bleeding disorders. Haemophilia. 2006; 12(3): 82-9. https://doi.org/10.1111/j.1365-2516.2006.01263.x

Mannucci PM. How I treat patients with von Willebrand disease. Blood. 2001; 97(7): 1915-9. DOI: 10.1182/blood.v97.7.1915

Wilde JT, Cook RJ. Von Willebrand disease and its management in oral and maxillofacial surgery. Br J Oral Maxillofac Surg. 1998; 36(2):112-8. DOI: 10.1016/s0266-4356(98)90178-4

Franchini M, Lippi G. Recent acquisitions in adquired and congenital von Willebrand disorders. Clinica Chimica Acta. 2007; 377(1-2):62-9. DOI: 10.1016/j.cca.2006.10.017

Cox-Gill J. Treatment of urgent bleeding in von Willebrand disease. Thrombosis Research. 2007; 120(1): S21-5. DOI: 10.1016/j.thromres.2007.03.013

Piot B, Sigaud-Fiks M, Huet P, Fressinaud E, Trossaërt M, Mercier J. Management of dental extractions in patients with bleeding disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 93(3): 247-50. DOI: 10.1067/moe.2002.121431

De Padua V, Romeo U, Santoro C, Bosco R, Baldacci E, Ferretti A, et al. Dental invasive procedures in von Willebrand disease outpatients treated with high purity FVIII/VWF complex concentrade (Fanhdi): experience of a a single center. Heliyon. 2020; 6(2): e03426. https://doi.org/10.1016/j.heliyon.2020.e03426

Franchini M, Rossetti G, Tagliaferri A, Pattacini C, Pozzoli D, Lorenz C, et al. Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers. Haemophilia. 2005; 11(5): 504-9. https://doi.org/10.1111/j.1365-2516.2005.01132.x

Rakocz M, Mazar A, Varon D, Spierer S, Blinder D, Martinowitz U, et al. Dental extraction in patients with bleeding disorders. Oral Surg Oral Med Oral Pathol. 1993; 75(3): 280-2. https://doi.org/10.1016/0030-4220(93)90135-Q

Lewandowski B, Wojnar J, Brodowski R, Mucha M, Czenczek-Lewandowska E, Brzęcka E. Dental extractions in patients with mild hemophilia A and hemophilia B and von Willebrand disease without clotting factor supplementation. Pol Arch Intern Med. 2018; 128 (7-8):488-90. https://doi.org/10.20452/pamw.4298

Published

2022-06-17

How to Cite

1.
Navas-Aparicio M del C, Acuña-Navas A. von Willebrand disease: practical considerations for the dentist. Literature review. Rev Estomatol Herediana [Internet]. 2022 Jun. 17 [cited 2024 Dec. 22];32(2):154-61. Available from: http://44.198.254.164/index.php/REH/article/view/4214

Issue

Section

REVIEW ARTICLE

Most read articles by the same author(s)